dt – epilepsy – Agreement on Bilateral Industrial R&D Cooperation (GSRT & IIA)

An overview of the dT-Epilepsy project

Project Overview

Over the last decade, TMS combined with EEG (TMS-EEG) has been successfully applied in diverse areas of neuroscience. Emerging evidence suggests that TMS-EEG may be used as a non-invasive tool for unraveling the pathophysiology of human epilepsies and holds significant diagnostic and therapeutic potential. Nevertheless, it remains of rather limited use in the field of epilepsy principally due to methodological reasons, such as the restricted depth and spatial extent of cortical stimulation achieved by available TMS techniques. This intractable heretofore problem can be approached with the use of novel coil designs, such as the H-coils (deep TMS).
In order to address the above-mentioned limitations of currently existing TMS-EEG systems, as related to epilepsy, dT-EPILEPSY proposes the development of a deep-TMS–EEG system allowing the optimization of transcranial stimulation over the epileptogenic zone. This approach is expected to open new pathways for the diagnosis, treatment and monitoring of patients with epilepsy.

Results and Publications

Work in progress

The Consortium

The dT-Epilepsy consortium consists of four partners from Greece Israel and the U.S.A.

Specifically, the Consortium consists of:
1. THessaloniki Software Solution S.A. (THESS S.A.), an SME from Greece which specializes in bioelectromagnetic simulations.
2. Aristotle University of Thessaloniki (A.U.Th) – The Clinical Neurophysiology Laboratory of the Medical School represented by Prof. Vasilios Kimiskidis and the collaborating members Prof. Dimitris Kugiumtzis at the Department of Electrical and Computer Engineering (AUTh) and Prof. Nikos Laskaris at the Department of Informatics (AUTh).
3. the company “Brain R&D”, which is a subsidiary of “Brainsway Ltd.” from Israel which specializes in the development and manufacture of the deep-TMS coils.
4. a non-funded partner, the Boston children’s Hospital / Harvard Medical School, Neuromodulation Program, represented by Prof. Alexander Rotenberg and the TMS lab supervisor Harper Kaye.

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