To this end, the following specific objectives will be pursued:

  • Objective 1: Construction of epilepsy-specific deep TMS coils in spherical models.

  • Objective 2: Optimization and validation of the epilepsy-specific deep TMS coils in anatomical models.

  • Objective 3: Development, testing and validation in healthy volunteers of deep TMS-EEG stimulation and analysis protocols.

  • Objective 4: Diagnostic validation of deep-TMS-EEG biomarkers in epilepsy.

  • Objective 5: Therapeutic validation of deep-TMS-EEG in epilepsy.